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ORCIDHirokazu Sugiyama
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2020 – today
- 2024
[j18]Kozue Okamura, Kota Oishi
, Sara Badr, Akira Yamada, Hirokazu Sugiyama:
Data-driven parameterization and development of mechanistic cell cultivation models in monoclonal antibody production processes: Shifts in cell metabolic behavior. Comput. Chem. Eng. 191: 108822 (2024)- 2023
- [j17]Daniel R. Lewin, Emilia M. Kondili, Ian T. Cameron, Grégoire Léonard, Seyed Soheil Mansouri, Fernando Gomes Martins, Luis A. Ricardez-Sandoval, Hirokazu Sugiyama, Edwin Zondervan:
Agile process systems engineering education: What to teach, and how to teach. Comput. Chem. Eng. 170: 108134 (2023) - [j16]Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Sara Badr, Hirokazu Sugiyama:
Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes. Comput. Chem. Eng. 171: 108141 (2023) - [j15]Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama:
A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation. Comput. Chem. Eng. 171: 108157 (2023) - [j14]Isuru A. Udugama, Sara Badr, Keita Hirono, Benedikt X. Scholz, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama:
The role of process systems engineering in applying quality by design (QbD) in mesenchymal stem cell production. Comput. Chem. Eng. 172: 108144 (2023) - 2022
- [j13]Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama:
Model-based comparison of batch and flow syntheses of an active pharmaceutical ingredient using heterogeneous hydrogenation. Comput. Chem. Eng. 156: 107541 (2022) - [j12]Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama:
Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality. Comput. Chem. Eng. 156: 107566 (2022) - [j11]Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama:
A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells. Comput. Chem. Eng. 163: 107851 (2022) - 2021
- [j10]Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama:
Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells. Comput. Chem. Eng. 144: 107150 (2021) - [j9]Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama:
Integrated design of biopharmaceutical manufacturing processes: Operation modes and process configurations for monoclonal antibody production. Comput. Chem. Eng. 153: 107422 (2021) - 2020
- [j8]Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama:
Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation. Comput. Chem. Eng. 132 (2020)
2010 – 2019
- 2019
- [j7]Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama:
Multiobjective decision-support tools for the choice between single-use and multi-use technologies in sterile filling of biopharmaceuticals. Comput. Chem. Eng. 122: 114-128 (2019) - [j6]Haruku Shirahata, Sara Badr, Shant Dakessian, Hirokazu Sugiyama:
Alternative generation and multiobjective evaluation using a design framework: Case study on sterile filling processes of biopharmaceuticals. Comput. Chem. Eng. 123: 286-299 (2019) - [j5]Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama:
Data mining algorithm for pre-processing biopharmaceutical drug product manufacturing records. Comput. Chem. Eng. 124: 253-269 (2019) - [c2]Takahiro Ishizaki, Kazuki Uchida, Hirokazu Sugiyama, Xu Han, Natsuki Hayasaka, Masaki Aikawa, Masaki Matsuura, Koki Tsushima, Takuto Shirai, Kazuhiko Shimomura:
Lasing characteristics of GalnAsP SCH-MQW Laser Diode on Directly-bonded InP/Si Substrate. OECC/PSC 2019: 1-3 - [c1]Koki Tsushima, Kazuki Uchida, Xu Han, Hirokazu Sugiyama, Masaki Aikawa, Natsuki Hayasaka, Masaki Matsuura, Takahiro Ishizaki, Takuto Shirai, Kazuhiko Shimomura:
Lasing Characteristics of GalnAsP SCH MQW High-mesa Laser on Silicon Substrate. OECC/PSC 2019: 1-3 - 2016
- [j4]Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler:
Data-driven tiered procedure for enhancing yield in drug product manufacturing. Comput. Chem. Eng. 87: 82-94 (2016) - [j3]Lukas Gallus Eberle, Elisabet Capón-García, Hirokazu Sugiyama, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler:
Rigorous approach to scheduling of sterile drug product manufacturing. Comput. Chem. Eng. 94: 221-234 (2016) - 2015
- [j2]Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama:
Systematic retrofitting methodology for pharmaceutical drug purification processes. Comput. Chem. Eng. 80: 177-188 (2015) - 2014
- [j1]Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt:
Improving lead time of pharmaceutical production processes using Monte Carlo simulation. Comput. Chem. Eng. 68: 255-263 (2014)
Coauthor Index
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